Although TSP has been reported to be successful in patients with device closure of interatrial septal communications, questions pertinent to its feasibility in patients with large devices Selleckchem Ulixertinib still remain. We sought to determine whether a “safe zone” for TSP could be visualised by computer tomography (CT), especially if larger device sizes for interatrial septal communication closure (IASC-C) had been used.\n\nRetrospective observational study of 20 patients who underwent CT for de novo chest pain occurring after IASC-C or as a diagnostic test for suspected

or proven coronary artery disease (CAD). Clinical follow-up was for 20.5 +/- 17.6 (6-84) months. CT was done18 +/- 10 (2-28) weeks after IASC-C. Device size and dimensions of both atria in the long and short axes were measured, as was the minimal distance of the device edge to the inferior and inferoposterior atrial floor.\n\nThe calculated minimal distance from the device edge to the inferior aspect (at 6 o’clock) of the (right or left) atrial floor was 7.2 +/- 6.5 (0-27) mm while that to the inferoposterior aspect (at 07:30 o’clock) was 5.3 +/- 4.2 (0-15) mm. In both locations, a distance of > 6 mm was documented in ten patients IPI-145 purchase (50%) while in nine patients (45%) a space of < 6 mm was shown in both locations. There was no correlation between atrial dimensions or device size and

minimal device distance to either wall.\n\nWith the exception of cases with the smallest devices (18 and 20 mm), neither device size nor atrial dimensions allow us to predict the feasibility of TSP in patients with a clamshell-type interatrial septal device in place, so that CT may be of help in determining whether a safe puncture space does exist in these patients.”
“PURPOSE. We investigated the vascular system in the far peripheral retina in eyes with pathologic myopia by LB-100 in vitro ultra-widefield fluorescein angiography (FA). METHODS. We analyzed retrospectively 230 with pathologic myopia (myopic refractive error bigger than 8 diopters [D] or axial length

bigger than 26.5 mm) and 42 emmetropic (refractive error smaller than +/- 2 D) controls who were examined with ultra-widefield FA by the Optos P200 system. Far peripheral retina was defined as the area anterior to the ampullae of the vortex veins. RESULTS. Retinal capillary telangiectasia was observed in the far periphery of 34 of 42 (81.0%) emmetropic eyes and in 90 of 115 (78.3%) highly myopic eyes. Retinal capillary microaneurysms were observed in 13 of 42 (31.0%) emmetropic eyes and in 60 of 115 (52.2%) eyes with pathologic myopia. The differences in the incidences of these two lesions were not significant. Areas of nonperfusion in the far periphery were found in two of 42 (4.8%) emmetropic eyes and in 95 of 115 (82.6%) eyes with pathologic myopia.