Conclusions CD133 may play an important role in chemoresistance and recurrence, thus representing a promising predictive marker for the prognosis of gastric cancer. J. Surg. Oncol. 2012; 106: 9991004. (c) 2012 Wiley Periodicals, Inc.”
“Aims: To

compare the existing model estimates of the appropriate rates of CYT387 solubility dmso radiotherapy for lung, breast and prostate cancers with actual radiotherapy rates in rural, semi-urban and urban areas, and in areas with short and long drive distances to cancer clinics in British Columbia.\n\nMaterials and methods: : All registered cases of lung, breast and prostate cancer diagnosed in British Columbia between 1997 and 2007 were identified. The proportion of cancers treated within 1 (RT(1y)) and 5 years (RT(5y)) of diagnosis were calculated according to rural, semi-urban and urban area, and areas associated with short and long drive distances to cancer clinics in British Columbia.\n\nResults: RT(1y) for lung, breast and prostate in urban CAL-101 molecular weight and rural areas were 47/45%, 57/46% and 31/30%, and for short and long drive times were 47/44%, 56/50% and 31/31% compared with model estimates for initial radiotherapy needs of 41-45%, 57-61% and 32-37%, respectively. RT5y for lung, breast and prostate in urban and rural areas were 52/47%, 59/48% and 42/39%, and for short and long drive times were 51/47%, 57/50% and 42/42% compared with model estimates for overall radiotherapy needs of

66-83%, 57-61% and 60-61%, respectively.\n\nConclusions: Radiotherapy rates vary between and within urban and rural areas in British Columbia. Radiotherapy rates for breast and lung cancer patients are higher, and closer to model estimates buy Dihydrotestosterone of need, in urban areas and short drive time areas. Radiotherapy rates do not vary with drive time or rural versus urban classification for patients with prostate cancer. (C) 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.”
“Background/Aims: The association between clinical symptoms and sleep disorders in functional dyspepsia (FD)-overlap syndrome has not been studied in detail.\n\nMethods: The subjects were

139 patients with FD, 14 with irritable bowel syndrome (IBS), 12 with nonerosive reflux disease (NERD), and 41 healthy volunteers. Gastric motility was evaluated with the C-13-acetate breath test. We used Rome III criteria to evaluate upper abdominal symptoms, and Self-Rating Questionnaire for Depression (SRQ-D) scores to determine depression status. Sleep disorders were evaluated with Pittsburgh Sleep Quality Index (PSQI) scores.\n\nResults: There were no significant differences in age, body-mass index, alcohol intake, and smoking rate between patients with FD alone and those with FD-overlap syndrome. The postprandial abdominal fullness score in patients with FD-NERD-IBS was significantly greater than that in patients with FD-NERD overlap syndrome (p<0.

Reduction in nucleobindin-2 expression inhibited EGF-stimulated MAPK kinase (S217/S221) and Erk phosphorylation

(T202/Y204). In contrast, there was no significant effect on EGF-stimulated EGF receptor phosphorylation, EGF receptor internalization, or 52-kDa Shcandc-Raf phosphorylation. Although kinase suppressor of Ras-1 and protein phosphatase 2A expression was not changed, intracellular calcium concentrations and PP2A activity was significantly increased in nucleobindin-2 knocked-down cells. Concomitant with these alterations in EGF-stimulated signaling, cell proliferation was significantly reduced in nucleobindin-2 knocked-down cells. Moreover, reduced nucleobindin-2 expression Selleck NVP-LDE225 in 3T3-L1 preadipocytes resulted in a greater extent of 3T3-L1 cell adipocyte differentiation. mTOR inhibitor Taken together, these data indicate that nucleobindin-2 regulates EGF-stimulated MAPK kinase/Erk signaling, cell proliferation, and adipocyte differentiation.

(Endocrinology 153: 3308-3319, 2012)”
“We studied the postural stability of 23 canoeing and kayaking young athletes and 15 healthy untrained age matched subjects during quiet and sensory conflicted stance (standing on stable and foam support with open and closed eyes). We measured with a force platform the center of pressure excursions and applied mean sway amplitude (MA), mean sway velocity (SV) and their Romberg ratios, and sway dispersion index to evaluate standing balance. During standing with eyes open, the athletes in comparison to non-athletes showed in sagittal and frontal plane greater MA and SV when the support was stable and smaller MA and SV when it was unstable. During standing with eyes closed, there were no differences between groups when the support was stable, however, the athletes sway faster and have smaller YH25448 manufacturer MA

than controls while standing on the foam support. During standing on stable support, Romberg ratios for MA and SV revealed that unlike non-athletes the athletes’ MA and SV were vision independent. However, while standing on unstable support the athletes’ MA and SV became vision dependent and even greater for the medio-lateral sway. Canoeists’ SV vision dependency in both planes was greater than for other groups. These results are in line with our hypothesis that young kayaking and canoeing athletes have a different from non-athletes model of sensory integration due to their specific sporting activity. One possible mechanism of this model may be a subtle re-adaptation deficit after disembarking to stable ground with diminished sensitivity of vision and vestibular apparatus.”
“Aim: To investigate the oncological short-term effects and acute side-effects of magnetic resonance imaging (MRI)-guided selective neoadjuvant radiochemotherapy (nRCT) for rectal cancer.

\n\nIn this review, we

will take a historical view and highlight some of the milestones that had an important impact on the development of gene therapy. We will also discuss briefly the safety and ethical aspects of gene therapy and address some concerns that have been connected with gene therapy as an important therapeutic modality. (C) 2013 Elsevier B.V. All rights reserved.”
“In vitro antiplasmodial activity of methanolic extracts of 16 medicinal plants was evaluated by fluorometric assay using PicoGreen. PXD101 Epigenetics inhibitor The IC50s, as determined by parasite DNA concentration, ranged from < 11 to > 200 and < 13 to > 200 mu g/ml for Plasmodium falciparum 3D7 and K1, respectively; and the most active extracts were those from Anogeissus leiocarpus and Terminalia avicennoides (< 11->= 14 mu g/ml). Aqueous, butanolic, ethyl acetate, and methanolic fractions of these two extracts revealed butanolic fraction to have a relatively better activity (IC50, 10-12 mu g/ml). Activity-guided chromatographic separation of the butanolic fraction on Sephadex LH-20 followed by nuclear magnetic resonance PU-H71 concentration and correlation high-performance liquid chromatography revealed the presence of

known hydrolysable tannins and some related compounds-castalagin, ellagic acid, flavogallonic acid, punicalagin, terchebulin, and two other fractions. The IC(50)s of all these compounds ranged between 8-21 mu g/ml (8-40 mu M) against both the strains. Toxicity assay with mouse fibroblasts showed all the extracts and isolated compounds to have IC50 >= 1500 mu g/ml, except for Momordica balsamina with < 1500 mu g/l. All the extracts and isolated compounds did not affect the integrity of human erythrocyte membrane at the observed IC(50)s. However, adverse effects manifest in a concentration-dependent fashion (from IC50 >= 500 mu g/ml).”
“We analyzed the combined effect of gender and CR on protein expression profile in liver. We identified

27 differentially expressed proteins involved in several cellular functions such as substrate metabolism, antioxidant systems, stress response, iron homeostasis and cardiovascular protection. This study reveals new cellular pathways liable to be similarly regulated in females and calorie restricted ROCK inhibitor rats and which could be related with the greater longevity in these animals.”
“Inhibition of blood vessel formation is a viable therapeutic approach in angiogenesis-dependent diseases. We previously used a combinatorial screening on vascular endothelial growth factor (VEGF)activated endothelial cells to select the sequence CPQPRPLC and showed that the motif Arg-Pro-Leu targets VEGF receptor-1 and neuropilin-1. Here, we evaluated and validated (D)(LPR), a derivative molecule with strong antiangiogenesis attributes. This prototype drug markedly inhibits neovascularization in three mouse models: Matrigel-based assay, functional human/murine blood vessel formation, and retinopathy of prematurity.

Salivary MMP-8, TIMP-1, and ICTP concentrations were higher in periodontitis subjects than those in controls. When only smokers were included in the analysis these differences were lost. The MMP-8/TIMP-1 ratio and the combination of MMP-8 and ICTP differentiated periodontitis and control groups even in smoker subjects.\n\nConclusion\n\nSalivary

MMP-8, TIMP-1, ICTP, and especially their ratios and combinations are potential candidates in the detection of advanced periodontitis. Differentiating periodontitis and control subjects with salivary MMP-8 Elafibranor manufacturer detection is dependent on the selected techniques.”
“Down syndrome (DS), commonly caused by an extra copy of chromosome 21 (chr21), occurs in approximately one out of 700 live births. Precisely how an extra chr21 causes over 80 clinically defined phenotypes

is not yet clear. Reduced representation bisulfite sequencing (RRBS) analysis at single base resolution revealed DNA hypermethylation in all autosomes in DS samples. We hypothesize that such global hypermethylation may be mediated by down-regulation of TET family genes involved in DNA demethylation, and down-regulation of REST/NRSF involved in transcriptional and epigenetic regulation. Genes located on chr21 were up-regulated by an average of 53% in DS compared to normal villi, while genes with promoter hypermethylation were GDC-0068 supplier modestly down-regulated. DNA methylation perturbation was conserved in DS placenta villi and in adult DS peripheral blood leukocytes, and enriched for genes known to be causally associated with DS phenotypes. Our data suggest that global epigenetic Screening Library changes may occur early in development and contribute to DS phenotypes.”
“Translocation of effector proteins via a type III secretion system (T3SS) is a widespread infection strategy among Gram-negative bacterial pathogens. Each pathogen translocates a particular set of effectors that subvert cell signaling in a way that suits its particular infection cycle. However, as effector unbalance might lead to cytotoxicity, the pathogens must employ mechanisms that regulate the intracellular effector

concentration. We present evidence that the effector EspZ controls T3SS effector translocation from enteropathogenic (EPEC) and enterohemorrhagic (EHEC) Escherichia coli. Consistently, an EPEC espZ mutant is highly cytotoxic. Following ectopic expression, we found that EspZ inhibited the formation of actin pedestals as it blocked the translocation of Tir, as well as other effectors, including Map and EspF. Moreover, during infection EspZ inhibited effector translocation following superinfection. Importantly, while EspZ of EHEC O157:H7 had a universal “translocation stop” activity, EspZ of EPEC inhibited effector translocation from typical EPEC strains but not from EHEC O157: H7 or its progenitor, atypical EPEC O55:H7.

“
“Objective: To examine the incidence rates of antipsychotic (AP) and antidepressant (AD) drug treatment in Norway and the proportions initiated in general practice and specialist care respectively.\n\nMethod: Data on all prescriptions of APs and ADs dispensed to the general population in Norway from 1 January 2004 until 31 August 2009 Raf inhibitor were extracted from the Norwegian Prescription Database. This information was merged with data about general practitioners (GPs) from the Norwegian Regular General Practitioner Scheme.\n\nResults: One-year incidence rates per 1000 inhabitants were 3.4 for APs and 8.6 for ADs. GPs initiated 58% of APs and 73% of ADs, while psychiatrists initiated 15%

and 6% respectively. Psychiatrists Geneticin purchase initiated treatment more often among younger patients, and they prescribed relatively newer drugs more commonly than GPs. A large share of incident users did not refill their prescriptions for APs (57%) or ADs (33%).\n\nConclusion: GPs have a key role as regards initiating treatment with APs and ADs in Norway, while psychiatrists’ influence seems

limited, particularly among older patients. Efforts for quality improvement of mental health care need to involve primary health care. In addition, an increased focus from psychiatrists towards the increasingly ageing part of the population seems requisite.”
“Introduction: Type 2 diabetes (T2D) is a complex metabolic disorder characterized by persistent hyperglycemia selleck products and a wide range of underlying metabolic defects. The prevalence and incidence of T2D are expected to dramatically increase in the near-future and consequently, there is a significant medical need for diabetes care.

Many targets are under investigation to lower the plasma glucose levels or increase the insulin sensitivity. Despite newer drug classes emerging as viable long-term treatment options for the management of T2D, achieving an optimal glycemic control along with sufficient effectiveness over the course of the disease remains a challenge. In this regard, among several G-protein-coupled receptors (GPCRs), GPR120 and GPR40 have recently been considered as viable targets for diabetes and metabolic disorders.\n\nAreas covered: This article reviews the current literature on the discovery and development of GPR120 agonists in diabetes and metabolic disorders and updates on the published patents in this field. The patent study for this review has been carried out using multiple electronic databases including SciFinder and Thomson Reuters Integrity.\n\nExpert opinion: A paradigm shift in the treatment of diabetes is needed, wherein a single therapeutic agent could target diabetes and its associated disorders such as high plasma glucose level and inflammation, with excellent safety and tolerability profile.

001 versues baseline). Improving lower limb hemodynamics is vital in preventing DVT. NMES resulted in larger ejected volumes compared to

SNS-032 IPC (x3 greater than foot-IPC and x1.7 greater than calf-IPC) more effectively emptying the veins and soleal sinuses. This is an important finding as DVT occurs predominantly in the soleal sinuses. NMES is silent and portable and thus does not suffer many of the issues associated with IPC. This work supports the potential widespread application of NMES in hospital and home settings where the risk of DVT formation is high.”
“Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) has a familial cause in 10 of patients. Despite significant advances in the genetics of the disease, many families remain unexplained. We performed whole-genome sequencing in five family members from a pedigree with autosomal-dominant classical ALS. A family-based elimination approach was used to

identify novel coding variants segregating with the disease. This list of variants was effectively shortened by genotyping these variants in 2 additional unaffected family members and 1500 unrelated population-specific controls. A novel rare coding variant in SPAG8 on chromosome 9p13.3 segregated with the disease and was not observed in controls. Mutations in SPAG8 were not encountered in 34 other unexplained ALS pedigrees, including 1 with linkage to chromosome 9p13.223.3. The shared haplotype containing the SPAG8 variant see more in this small pedigree was 22.7 Mb and overlapped with the core 9p21 linkage locus for ALS and frontotemporal dementia. Based on differences in coverage depth of known variable tandem repeat regions between affected and non-affected family members, the shared haplotype was found to contain an expanded hexanucleotide (GGGGCC)(n) repeat in C9orf72 in the affected members. Our results demonstrate that rare coding variants identified by whole-genome sequencing can tag a shared haplotype containing a non-coding pathogenic mutation and that changes in coverage depth can be used to reveal tandem repeat expansions. It also confirms (GGGGCC)n repeat expansions

in C9orf72 as a cause of familial ALS.”
“The questions of the title have been considered in several ways. First, indications Entinostat in vivo of the traits which make us humans were considered. Then the behavior and culture concepts were examined, and the biology and culture interactions discussed, with an emphasis on the similarities and differences between the genetic and cultural transmissions. Next diverse types of selective pressures were reviewed, and finally pessimistic and optimistic views of our future contrasted. Vigorous action against acts which lead to exclusion and discriminatory policies against human subjects is needed.”
“Active avoidance (AA) is an important paradigm for studying mechanisms of aversive instrumental learning, pathological anxiety, and active coping.

Contractile myofibroblasts drive this fibroproliferative disorder, whereas stem cells have recently been implicated in preventing fibrosis. Therefore, the authors tested the role of stem cells in modulating myofibroblast activity in Dupuytren’s disease. Methods: The authors compared the effect of co-culturing Dupuytren’s myofibroblasts with either adipose-derived or bone-marrow-derived stem cells on isometric

force contraction and associated levels of -smooth muscle actin mRNA and protein expression. The authors also tested the effect of these stem cells on Dupuytren’s myofibroblast proliferation and assessed whether this was mediated by cell-to-cell contact or by a paracrine mechanism. Results: Addition of adipose-derived stem cells to Dupuytren’s myofibroblasts reduced the contraction of the latter, HM781-36B research buy with a corresponding reduction of -smooth muscle actin protein expression, probably through a dilution effect. In contrast, bone marrow-derived stem cells increased myofibroblast contractility. In addition, adipose-derived stem cells inhibit myofibroblast proliferation and mediate these effects by soluble factors, influenced by cell-to-cell contact-dependent signaling. Conclusion: Adipose-derived stem cells inhibit the contractile myofibroblast in Dupuytren’s disease, and these findings lend support to the potential benefit of

lipografting in conjunction with aponeurotomy as a novel strategy for the treatment of Dupuytren’s disease.”
“Mercaptododecyl glycosides containing a terminal beta-galactosyl

group were prepared from D-galactose or from D-lactose via hexa-O-acetyl-lactal (10) as a key intermediate. https://www.selleckchem.com/products/MS-275.html Interactions of these glycolipids (5 kinds) ACY-241 clinical trial and galectins (beta-galactoside binding lectins, 6 species) were evaluated by surface plasmon resonance (SPR) method. High binding responses were observed for the lactoside, 2-deoxy-lactoside, and lactosaminide with some galectins (Gal-3, -4, -8), whereas the galactoside and 2,3-dideoxy-lactoside showed low binding activities. (C) 2010 Elsevier Ltd. All rights reserved.”
“Objective To determine the prevalence of upregulation of interferon (IFN) type I inducible genes, the so called ‘IFN type I signature’, in CD14 monocytes in 69 patients with primary Sjogren’s syndrome (pSS) and 44 healthy controls (HC) and correlate it with disease manifestations and expression of B cell activating factor (BAFF).\n\nMethods Expression of IFI44L, IFI44, IFIT3, LY6E and MX1 was measured using real time quantitative PCR in monocytes. Expression values were used to calculate IFN type I scores for each subject. pSS patients positive for the IFN type I signature (IFN score >= 10) and patients negative for the signature (IFN score<10) were then compared for clinical disease manifestations and BAFF expression. A bioassay using a monocytic cell line was performed to study whether BAFF mRNA expression was inducible by IFN type I activity in serum of patients with pSS.

93 (95% CI = 0.91-0.95).\n\nConclusions: (18)FDG PET-CT has moderate sensitivity and specificity for detection of gastric cancer recurrence after surgical resection. Crown Copyright (c) 2013 Published by Elsevier Ltd. All rights reserved.”
“Background: TNF-alpha antagonists may increase the risk of herpes zoster (HZ), as well as the duration and severity. Recently, the monoclonal antibody ustekinumab, blocking the p40 subunit of IL-12 and IL-23, has been introduced for treating moderate to severe plaque psoriasis. There are no PubMed reports of HZ occurring in people receiving ustekinumab treatment. Common HZ was reported in clinical trials. Observation: Two patients with

severe psoriasis treated with ustekinumab developed severe contiguous multidermatomal HZ 1 and 9 months after treatment initiation. Discussion: The occurrence of HZ after the instauration of ustekinumab suggests a causal relationship. Indeed, Dactolisib research buy the inhibition of the p40 subunit of IL-12 shifts the immune response towards a Th1 profile with diminished IFN-gamma and TNF-alpha expression, decreasing the antiviral immune response. Conclusion: Ustekinumab is probably a risk factor click here for developing HZ. Anti-HZ vaccination prior to ustekinumab treatment should be considered. Copyright (C) 2011 S. Karger AG, Basel”
“A new

species of flower flies is described from China (Sichuan & Yunnan: Hengduan Mountains), Sericomyia khamensis Thompson & Xie). A key is provided A-1210477 to the species of the subtribe Sericomyiina found in China along with nomenclatural and taxonomical notes on them.”
“Encouraged by the interesting biological activities associated

with chalcones and benzo[b]furan derivatives, herein are reported the synthesis, spectroscopic identification and antibacterial activity of benzo[b]furan chalcone derivatives 6a-o derived from 1-(7-methoxy-2-(2,4,6-trimethoxyphenyl)benzofuran-5-yl)ethanone 5 in a few high yielding steps from commercially available 1,3,5-trimethoxybenzene and 5-iodovanillin and various benzaldehydes. The synthesized targets have been screened for their antibacterial activity against Escheria coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococus pyogenes, while using Norfloxacin as the standard drug. Among all the compounds 6a-o, the compounds 6n, 6o, 6l and 6m exhibit excellent to equipotent activity while the compounds having the alkoxy substituent in the series display good to moderate activity.”
“Background/aims. In this present study, we aimed: (i) To clarify if prediabetes is associated with subclinical inflammation independent of underlying obesity, and (ii) to evaluate the effect of postload glucose concentration on subclinical inflammation markers in a group of patients with elevated fasting glucose. Material and methods.

The CO2 absorption and regeneration properties of this novel regenerable potassium-based dry sorbent were measured in a fixed-bed reactor during multiple absorption/regeneration cycles at low temperature conditions (CO2 absorption at 50-100 degrees C and regeneration at 130-200 C). The total CO2 capture capacity of the KZrl sorbent was maintained during the multiple CO2 absorption/regeneration cycles. The XRD patterns and FTIR analyses of the sorbents after CO2 absorption showed the KHCO3 phase only except for the ZrO2 phase used as support.

Even after 10 cycles, any other new structures resulting from the by-product during CO2 absorption were not observed. This phase could be easily converted into the Small molecule library original phase during regeneration, even at a low temperature (130 C). The KZrl sorbent developed in this study showed excellent characteristics in CO2 absorption and regeneration in that

it satisfies the requirements of a large Elafibranor manufacturer amount of CO2 absorption (91.6 mg CO2/g sorbent) and the complete regeneration at a low temperature condition (1 atm, 150 degrees C) without deactivation. (C) 2008 Elsevier B.V. All rights reserved.”
“Background. Gestational diabetes is connected with fetal macrosomia and higher perinatal mortality and morbidity rates. The usually quoted literature, which causes so much anxiety among pregnant women and an increased number of cesarean sections, is often dated, from the times when pregnancy monitoring methods were not as highly developed as they are now, comes from heterogeneous populations, and does not take into consideration the age and ethnicity of women. Screening for gestational diabetes mellitus (GDM), diagnostic tests, and special programs for diabetic pregnant women are very expensive and time consuming. It is worthwhile then to try to evaluate their cost and see if reducing it would affect the clinical results.\n\nObjectives. The aim of this JNK-IN-8 nmr study was to identify the real cost reduction and clinical advantages/disadvantages of replacing the 1-hr 50-g glucose challenge test (GCT) with the glucometer (stick method).\n\nMaterial and Methods. Two hundred and two

pregnant women from the population of this clinic attended screening for GDM by both enzymatic and stick method. The criteria for both measurements were the same. The positively screened women received a one-step diagnostic test and only they participated in the clinic’s diabetic program.\n\nResults. The results showed that replacing the enzymatic method by the stick method would reduce the total cost of screening for GDM by 90%. It was also calculated that the total cost of screening by this method followed by the diagnostic test would be 9.5 times lower than screening by the enzymatic method. It would have no harmful effects on perinatal outcome and would even make it possible to shorten the time between screening and treatment of GDM by about 7 days.\n\nConclusions.

However, conditional deletion of Wnt4 in interstitial cells did not reduce myofibroblast proliferation, cell number, or myofibroblast gene expression during fibrosis. Because the injured kidney expresses multiple Wnt ligands that might compensate learn more for the absence of Wnt4, we generated a mouse model with constitutive activation of canonical Wnt/-catenin signaling in interstitial pericytes and fibroblasts. Kidneys from these mice exhibited spontaneous myofibroblast differentiation in the absence of injury. Taken together, Wnt4 expression in renal fibrosis

defines a population of proliferating medullary myofibroblasts. Although Wnt4 may be dispensable for myofibroblast transformation, canonical Wnt signaling through -catenin stabilization is sufficient to drive spontaneous myofibroblast differentiation in interstitial pericytes and fibroblasts,

emphasizing the importance of this pathway in renal fibrosis.”
“Introduction. Despite advances in therapeutics, graft loss associated with chronic allograft dysfunction (CAD) remains high. Urinary proteomic analysis is a noninvasive method that could be used to detect and evaluate CAD in renal transplant recipients. This study was aimed to establish the normal proteome map of stable transplant patients and to validate the utility of two-dimensional difference gel electrophoresis (2DE-DIGE) in identifying new candidates as urinary biomarkers of CAD.\n\nMethods. Selleckchem BTK inhibitor Morning spot urine samples that were collected from kidney transplant recipients with biopsy-proven interstitial fibrosis and tubular atrophy (IFTA) stages 0-I-II/III (n=8/group) under immunosuppressive treatment with tacrolimus plus mycophenolate with or without prednisone.

2DE silver staining and mass spectrometry analyses were used to establish the normal proteome map, and 2DE-DIGE and mass spectrometry were used to identify proteins exhibiting differential abundance.\n\nResults and Conclusions. This study defines the normal proteome of stable renal transplant patients, which is composed of several plasma proteins, as well as of immunologic proteins that are probably specific to transplant recipients. The 2DE-DIGE study showed 19 proteins with SB203580 nmr differential concentrations, depending on the IFTA histologic score. These 19 proteins could be used as urinary biomarkers of the severity of IFTA in renal transplant recipients.”
“A resonance light scattering (RLS) method has been developed using a uranyl (UO22+) specific DNAzyme and gold nanoparticles (AuNPs). In this strategy, the cleavage of the substrate strand (SDNA) of DNAzyme results in releasing a shorter duplex in the presence of UO22+, leading to the aggregation of AuNPs and the increase of RLS intensity. The response signals linearly correlated with the concentration of UO22+ over the range of 1.36 x 10(-8)-1.50 x 10(-7) mol L-1. The limit of detection (LOD) is 4.09 x 10(-9) mol L-1. The method has excellent selectivity and higher sensitivity.