“
“In altricial and semi-altricial species, asynchronous hatching gives the first chicks to hatch an initial advantage over other siblings and often leads to the elimination of the smallest chicks. Both baseline corticosterone and acute stress-induced corticosterone levels have been shown to be higher in food deprived chicks than in chicks fed ad libitum. However, Volasertib in vitro first-hatched chicks have also been shown to exhibit higher corticosterone levels than last-hatched chicks, suggesting an influence of the initial differences between eggs on corticosterone levels. We subjected single-chicks of southern rockhopper penguins

Eudyptes chrysocome chrysocome to a standardised capture-stress protocol. In this

species having very dimorphic two-egg clutches, we examined whether corticosterone levels were different between the two chick categories and tested for the effect of body condition controlled by the chick category. Neither body sizes, nor corticosterone levels differed between A- and B-chicks at 18 days. In contrast to baseline corticosterone levels, acute stress-induced levels of corticosterone were negatively correlated to body condition: chicks with a good body condition had lower acute stress-induced levels of corticosterone than chicks with a poor condition, whatever the chick category. ABT-737 order Our results do not support the idea that initial differences in egg characteristics could drive the difference in corticosterone Lapatinib clinical trial levels between siblings. On the contrary, they show that the A-egg of rockhopper penguins has, when reared

alone, the same intrinsic potential to develop into a fledged chick as the B-egg. Later differences in body condition appear to lead to variation in the acute stress-induced levels of corticosterone. (C) 2010 Elsevier Inc. All rights reserved.”
“In this study, a mineralized collagen coating was electrolytically deposited onto titanium. The results showed that the mineralized collagen coatings with dense or porous morphology could be obtained. The mineral phase was mainly hydroxyapatite. In vitro evaluation showed the mineralized collagen coatings were stable in Kokubo’s simulated body fluid, and displayed a good cytocompatibility in the cell multiplication test. The mineralized collagen coatings loaded with vancomycin hydrochloride showed an inhibitory effect on the growth of S. aureus. The present mineralized collagen coating demonstrates good suitability for surface modification of orthopedic metal implants.”
“The multi-regional clinical trials (MRCTs) being administered in different regions of the world now play a major role in providing evidence for the efficacy and safety of new drugs amidst the simultaneous global development and worldwide registration of such drugs, in support of the expeditious availability of medical products to patients.