Methods. We searched PubMed, Embase, and Cochrane library databases up to February 2014 looking for eligible studies. Summary relative risk (RR) estimates and 95% confidence intervals (Cls) were used to calculate the risk using random-effects models. Results. A total of 14 (4 randomized controlled trials, 5 cohorts, and 5 case-control) studies, involving 12,904 gynecologic cancer cases, contributed to the analysis. Pooled results

indicated a non-significant decrease of total gynecologic cancer risk among statin users (RR = 0.89; 95% Cl, 0.78-1.01). Stratified analyses across cancer site revealed a modest protective effect of statin on ovarian cancer (RR = 0.79; 95% Cl, 0.64-0.98), while HIF inhibitor no association was found for endometrial cancer (RR = 0.90; 95% CI, 0.75-1.07). The effect of statin use against cervical cancer and vulvar cancer is not conclusive. Furthermore, long-term statin use ( bigger than 5 years use) did not significantly affect the risk of endometrial cancer (RR = 0.69; 95% CI, 0.44-1.10), but had an obvious decrease on the risk of ovarian cancer (RR = 0.48; 95% CI, 0.28-0.80). Conclusions. Our results suggest that statin use was inversely associated with ovarian cancer risk, and the association was stronger for long-term statin use ( bigger than

5 years). The evidence for a protective effect of statin use against other gynecologic cancers is suggestive but not conclusive, which deserves further investigation. (C) 2014 Elsevier Inc. All rights reserved.”
“Current biofuel prospects face many hurdles to becoming mass produced, BVD-523 mw such as ethanol which is lower in energy content and incompatible with the petroleum-based fuel infrastructure 3-deazaneplanocin A purchase we live in. Consequently, the search is on for an organism that either produces naturally or can be engineered to produce a

fuel source that is both comparable in energy content and compatible to the current petroleumbased infrastructure. The pennate diatom Phaeodactylum tricornutum has long been a model species for studies of diatom growth, biochemistry, and lipid accumulation (e.g., triglycerides). In this study, we have used gas chromatography/mass spectrometry (GC/MS) to examine the hydrocarbons produced by P. tricornutum at 20 and 30 degrees C. P. tricornutum did indeed produce hydrocarbons similar to those found in petroleum-based fuels, namely octane (C-8), undecane (C-11), nonadecane (C-19), and heneicosane (C-21) at 20 degrees C. At 30 degrees C, however, the alkanes produced were instead heptadecane (C-17), octadecane (C-18), nonadecane (C-19), and eicosane (C-20). We also observed three alkenes-heptadecene (C-17:1), octadecene (C-18:1), and nonadecene (C-19:1)-which were not present at the lower temperature. If having organisms such as P.